Researchers at Rutgers School of Dental Medicine have identified why infections around dental implants resist antibiotic treatment. A study published in PNAS Nexus reveals that bacteria corrode titanium implants, releasing microscopic particles into surrounding tissues. These particles interfere with immune cells called macrophages, trapping them in excessive inflammation that destroys jawbone. The discovery addresses a widespread problem affecting 10% to 20% of implant patients, costing healthcare systems over $1 billion annually.
Scientists traced the immune system disruption to a calcium channel called TRPC1 in macrophages. When titanium particles coated with bacterial toxins are consumed by immune cells, this channel becomes activated, preventing the cells from fighting bacteria effectively. Laboratory experiments with genetically engineered mice showed that disabling this channel prevented the destructive disease process. Researchers are now evaluating drugs targeting this molecular pathway as potential treatments for peri-implantitis, while emphasizing that proper implant cleaning with nonabrasive techniques remains the strongest preventive measure.
Source: Read the full story at ScienceDaily
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